Newbury, J.B. et al. (2019)
JAMA Psychiatry (Forthcoming)

This long-term population-based cohort study of 2,232 children born in the UK who were surveyed at 18 years of age on psychotic experiences. Their urbanicity was estimated using census data to determine pollution exposure, as well as 2 other locations the participant reported spending the majority of their time. The study found that air pollution exposure, particularly NO2 and NOx was associated with increased psychotic experiences. ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀
30.2% of the participants reported at least 1 psychotic experience. Psychotic experiences were more common in participants with higher levels of pollution exposure, including NO2 (OR 1.71), NOx (OR 1.72) and PM2.5 (OR 1.45). These statistics were adjusted for family stress, childhood psychosis symptoms, substance use, socioeconomic status, and social conditions. ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀
Proposed mechanisms include both biological (such as neuroinflammation and lower vitamin D levels) and psychological factors (such as stress). Study indicates the need for investigating factors of urbanicity affecting mental health. ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀
Newbury JB, Arseneault L, Beevers S, et al. Association of Air Pollution Exposure With Psychotic Experiences During Adolescence. JAMA Psychiatry. Published online March 27, 201976(6):614–623. doi:10.1001/jamapsychiatry.2019.0056