Mori et al. (2011)
Biomedical Research, 32(1)

The ancient Chinese relied on Lion’s Mane mushroom for centuries to alleviate digestive pain and bestow longevity long before the advent of modern medicine. Today, Lion’s Mane is being cultivated on an industrial scale for its nootropic properties as a potential cognitive enhancer and natural health aid. ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀
One of the first studies of its kind, a 2011 report by Mori et al. found that Lion’s Mane promotes nerve growth factor secretion in vitro and in vivo - which is essential for central nervous system maintenance. In other words, Lion’s Mane has demonstrated that it can maintain and regenerate neurons (brain cells) and contribute to long-term healthy cognitive function. For this reason, Lion’s Mane supplements, and the mushroom itself, is being sought after as a potential treatment and preventative measure against dementia. ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀
This 2011 study specifically looked at older Japanese adults with mild cognitive impairment who ingested 3 grams of Lion’s Mane daily for 4 months. The participants showed steady improvement until the supplementation stopped, at which point their cognitive test scores decreased significantly.